Lodging Historic

Main Street Inn

221 North Main Street
Ste. Genevieve, MO 63670
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Originally built in 1882, as the Meyer Hotel, the Main Street Inn B&B has long been one of Missouri’s finest bed and breakfast establishments. After recently undergoing an extensive year-long renovation, the new owners and innkeeper are thrilled to re-open the Main Street Inn B&B and welcome our guests to what we hope will be a truly wonderful experience. If you are looking for a relaxing and peaceful getaway, the Main Street Inn B&B is the perfect destination.


The Southern Hotel (c1805)

146 South Third Street
Ste. Genevieve, MO 63670

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Step gently into the time when riverboats plied the mighty Mississippi and weary travelers looked forward to the hospitality of this famous 200-year-old landmark hotel. The graciousness of the past is carefully blended with modern comforts to make your stay a very special experience.


White Cliff Manor Bed & Breakfast and Gardens

200 Second St.
St. Mary, MO
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Circa 1879, beautiful and elegant, White Cliff Manor is a ten acre estate on the bluffs of the Mississippi River Valley. The area includes Ste. Genevieve Wineries and Historic District. Enjoy magnificent views, private grounds, first rate accommodations and deluxe American breakfast.